現貨moradec AH-106-PB說明書(shu)
αHFc CL PBD
抗人IgG Fc PBD抗體(ti) 與(yu) 可裂解連接子
目錄號：AH-106-PB
αHFc CL PBD是抗人IgG Fc特異性抗體(ti) ，與(yu) 吡咯並二氮雜平（PBD）通過可裂解接頭偶聯。抗體(ti) 部分是對人IgG的Fc區特異的多克隆抗體(ti) 。吡咯並二氮卓（PBD）是一種細胞毒性小分子，它與(yu) 小凹槽結合，並與(yu) 的特定位點交叉連接。連接PBD和抗體(ti) 的可裂解接頭在細胞外液中是穩定的，但一旦綴合物通過內(nei) 吞作用進入細胞，就會(hui) 被內(nei) 體(ti) 中的組織蛋白酶裂解。
| Anti-human IgG Fc-PBD Antibody with Cleavable Linker | Catalog Number: AH-106-PB |
| αHFc-CL-PBD is anti-human IgG Fc specific antibody conjugated to pyrrolobenzodiazepine (PBD) with a cleavable linker. The antibody portion is a polyclonal antibody which is specific to the Fc region of human IgGs. Pyrrolobenzodiazepine (PBD) is a cytotoxic small molecule which binds to minor groove and cross-links specific sites of . The cleavable linker connecting PBD to the antibody is stable in extracellular fluid, but is cleaved by cathepsin in endosome once the conjugate has entered a cell via endocytosis. | |
電話
QQ掃一掃
