現貨moradec AH-102-DD說明書(shu)
αHFc CL PNU
抗人IgG Fc-PNU159682抗體(ti)
目錄號：AH-102-DD
αHFc CL PNU是與(yu) PNU-159268結合的抗人IgG Fc特異性抗體(ti) ，具有可裂解接頭。抗體(ti) 部分是對人IgG的Fc區特異的多克隆抗體(ti) 。PNU-159682是內(nei) 柔比星的衍生物，是一種細胞毒性小分子，通過插入和抑製複製導致細胞死亡。連接PNU-159682與(yu) 抗體(ti) 的可裂解接頭在細胞外液中是穩定的，但一旦綴合物通過內(nei) 吞作用進入細胞，則被內(nei) 體(ti) 中的組織蛋白酶裂解。
| Anti-human IgG Fc-PNU159682 Antibody with Cleavable Linker | Catalog Number: AH-102-DD |
| αHFc-CL-PNU is anti-human IgG Fc specific antibody conjugated to PNU-159268 with a cleavable linker. The antibody portion is a polyclonal antibody which is specific to the Fc region of human IgGs. PNU-159682, a derivative of nemorubicin, is a cytotoxic small molecule which causes cell death by intercalating and inhibiting replication. The cleavable linker connecting PNU-159682 to the antibody is stable in extracellular fluid, but is cleaved by cathepsin in endosome once the conjugate has entered a cell via endocytosis. | |
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