現貨moradec AH-207-DX說明書(shu)
Fab-αHFc-CL-DX8951
Fab抗人IgG Fc-DX9851抗體(ti)
目錄號：AH-207-DX
Fab-αHFc-CL-DX8951是抗人IgG Fc特異性抗體(ti) 的Fab片段，與(yu) 甲磺酸艾替康（DX8951）結合，具有可裂解的接頭。抗體(ti) 部分是對人IgG的Fc區特異的多克隆抗體(ti) Fab片段。甲磺酸埃克替康（DX8951）是一種拓撲異構酶I抑製劑。連接DX8951和抗體(ti) 的可裂解接頭（GGFG）在細胞外液中是穩定的，但一旦綴合物通過內(nei) 吞作用進入細胞，就會(hui) 在內(nei) 體(ti) 中被裂解。Fab 2°ADC的單價(jia) 性質在某些應用中可能比全長IgG 2°ADC具有一些優(you) 勢。
| Fab Anti-Human IgG Fc-DX9851 Antibody with Cleavable Linker | Catalog Number: AH-207-DX |
| Fab-αHFc-CL-DX8951 is a Fab fragment of anti-human IgG Fc specific antibody conjugated to exatecan mesylate (DX8951) with a cleavable linker. The antibody portion is a polyclonal antibody Fab fragment specific to the Fc region of human IgGs. Exatecan mesylate (DX8951) is a topoisomerase I inhibitor. The cleavable linker (GGFG) connecting DX8951 to the antibody is stable in extracellular fluid, but is cleaved by in endosome once the conjugate has entered a cell via endocytosis.The mono-valence nature of Fab 2°ADC may have some advantage in certain applications than the full length IgG 2°ADC. | |
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