現貨moradec AH-107-DX說明書

現貨moradec AH-107-DX說明書(shu)

αHFc-CL-DX8951

抗人IgG Fc-DX8951抗體(ti) 與(yu) 可裂解連接子

目錄號：AH-107-DX

αHFc-CL-DX8951是一種抗人IgG Fc特異性抗體(ti) ，與(yu) 甲磺酸埃克替康（DX8951）結合。抗體(ti) 部分是對人IgG的Fc區特異的多克隆抗體(ti) 。甲磺酸埃克替康（DX8951）是一種拓撲異構酶I抑製劑。連接DX8951和抗體(ti) 的可裂解接頭（GGFG）在細胞外液中是穩定的，但一旦綴合物通過內(nei) 吞作用進入細胞，則在內(nei) 體(ti) 中被裂解。

αHFc-CL-DX8951

Anti-human IgG Fc-DX8951 Antibody with Cleavable Linker	Catalog Number: AH-107-DX
αHFc-CL-DX8951 is anti-human IgG Fc specific antibody conjugated to exatecan mesylate (DX8951) with a cleavable linker. The antibody portion is a polyclonal antibody which is specific to the Fc region of human IgGs. Exatecan mesylate (DX8951) is a topoisomerase I inhibitor. The cleavable linker (GGFG) connecting DX8951 to the antibody is stable in extracellular fluid, but is cleaved by in endosome once the conjugate has entered a cell via endocytosis.